MIT researchers unravel bacteria communication pathways
CAMBRIDGE, Mass. -- MIT researchers have figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment.
The researchers also successfully rewired the cellular communications pathways that control those responses, raising the possibility of engineering bacteria that can serve as biosensors to detect chemical pollutants. The work is reported in the June 13 issue of Cell.
Specificity in signal transduction systems:
Another major focus in the lab is understanding how cells maintain the specificity of signaling systems. Given the highly related nature of the two-component signaling proteins in bacteria, how do cells maintain the insulation of different pathways? What prevents harmful cross-talk? How are signals integrated? We use both computational and experimental approaches to answer these questions.
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